赵旵军 (ZHAO HanJun)
     

  • 个人简历

    教授 (Professor)，博士生导师

    个人邮箱：hanjunzhao@fudan.edu.cn

    办公地址：复旦大学上海医学院2号医学科研楼

    教育及工作经历：2013年香港大学微生物系博士毕业， 2013-2020年香港大学博士后， 2020-2024年香港大学研究助理教授， 2023-2024年帝国理工学院访问学者，2020年至今香港病毒和疫苗研究中心首席研究员。

    学术兼职：帝国理工学院访问学者，香港病毒和疫苗研究中心首席研究员、香港大学微生物系荣誉助理教授


  • 研究方向

    1) 大广谱抗病毒和细菌多肽研究 (Broad-spectrum antiviral and antibacterial peptide studies)

    2) 纳米颗粒病毒缺陷干扰基因研究 (Peptide-nanoparticle viral defective interfering gene studies)

    3) 疫苗研究 (Vaccine studies including influenza and coronavirus vaccines)


  • 重要学术贡献

    Publications:

    1. Manxue Jia#, Hanjun Zhao# (Co-first), Nicholas C. Morano#, Hong Lu, Yin-Ming Lui, Jordan E. Becker, Kwok-Yung Yuen, David D. Ho, Peter D. Kwong, Lawrence Shapiro, Kelvin Kai-Wang To*, Xueling Wu*. Human neutralizing antibodies target a conserved lateral patch on H7N9 hemagglutinin head. Nature Communications. 2024,15:4505. doi.org/10.1038/s41467-024-48758-4. (May 27, 2024, 2023IF:16.6).

    2. Yee-Man Au-Yeung#, Chuyuan Zhang#, Hanjun Zhao*(Corresponding author), Bao-Zhong Zhang*, Jian-Dong Huang*. Engineered intranasal virus trap provides effective protection against SARS-CoV-2 infection in hamsters. Advanced Functional Materials. 2023, 2305120. doi.org/10.1002/adfm.202305120 (July 8, 2023; 2022IF=19.0)

    3. Qiulu Ding, Hanjun Zhao*(Corresponding author). Long-term effects of SARS-CoV-2 infection on human brain and memory. Cell Death Discovery. 2023, 9:196. doi.org/10.1038/s41420-023-01512-z. (Jun 29, 2023; 2021IF=7.113), Times cited: 10 (Google Scholar)

    4. Hanjun Zhao* (First and Corresponding author), Lu Lu, Zheng Peng, Lin-Lei Chen, Xinjin Meng, Chuyuan Zhang, Jonathan Daniel Ip, Wan-Mui Chan, Allen Wing-Ho Chu, Kwok-Hung Chan, Dong-Yan Jin, Honglin Chen, Kwok-Yung Yuen, Kelvin Kai-Wang To*. SARS-CoV-2 Omicron variant shows less efficient replication and fusion activity when compared with Delta variant in TMPRSS2-expressed cells. Emerging Microbes & Infections. 2022, 11(1):277-283. DOI: 10.1080/22221751.2021.2023329. (Dec 11, 2022).     

      Impact factor: 19.568; Ranking of journal in “Infectious Diseases”: 8/94;

      Times cited: 390 (Google Scholar)

      Significance: This was the first study to comprehensively demonstrate Omicron variant showing more reliance on endocytosis pathway with less fusion activity. This publication was selected for 2022 Best Papers Award First Place, Emerging Microbes and Infections

    5. Hanjun Zhao*(First and Corresponding author), Chuyuan Zhang, Hoiyan Lam, Zheng Peng, Xinjie Meng, Lu Lu, Man Lung Yeung, Kin-Hang Kok, Jasper Fuk-Woo Chan, Kelvin K. W. To, Kwok-Yung Yuen*. Peptidic defective interfering gene nanoparticles against Omicron and Delta SARS-CoV-2 variants and influenza A virus in vivo. Signal Transduction and Targeted Therapy. 2022, 7:226, doi: 10.1038/s41392-022-01138-0. (Aug 3, 2022; 2021IF:38.126). Impact factor: 38.126; Ranking of journal in Biochemistry & Molecular Biology: 4/296.

      Significance: This is an important report that we investigated influenza DIG against avian and pandemic influenza virus. Moreover, we developed a novel high-efficient gene delivery vector for gene delivery in the lung airway to significantly inhibit SARS-CoV-2 Delta and Omicron variant replication in hamsters. 

    6. Hanjun Zhao#*(First and Corresponding author), Kelvin K. W. To#, Chuyuan Zhang, Hoiyan Lam, Zheng Peng, Xinjie Meng, Xiankun Wang, Jianpiao Cai, Anna Jinxia Zhang, Bingpeng Yan, Man Lung Yeung, Jasper Fuk-Woo Chan, Kwok-Yung Yuen*. A trifunctional peptide broadly inhibits SARS-CoV-2 Delta and Omicron variants in hamsters. Cell Discovery, 2022, 8(1):62. DOI: 10.1038/s41421-022-00428-9. (June 30, 2022; 2021IF:38.101). Impact factor: 38.101; Ranking of journal in Cell Biology: 7/194;

      Significance: This is the first report that a basic human-defensin peptide could show potent antiviral activity by inhibiting viral entry, fusion and release. The application of inhibiting viral release could be used for blocking viral transmission.

    7. Chuyuan Zhang, Xinjie Meng, Hanjun Zhao*(Corresponding author). Comparison of Cell Fusions Induced by Influenza Virus and SARS-CoV-2. International Journal of Molecular Sciences. 2022, 23(13): 7365. DOI: 10.3390/ijms23137365. (July 01, 2022; 2021IF:6.208). Ranking of journal in Biochemistry & Molecular Biology: 69/296. Times cited: 3 (Google Scholar)

    8. Hanjun Zhao, Kelvin K. W. To, Hoiyan Lam, Xinxin Zhou, Jasper Fuk-Woo Chan, Peng Zheng, Andrew C. Y. Lee, Jianpiao Cai, Wan-Mui Chan, Jonathan Daniel Ip, Chris Chung-Sing Chan, Man Lung Yeung, Anna Jinxia Zhang, Allen Wing Ho Chu, Shibo Jiang, Kwok-Yung Yuen. Cross-linking peptide and repurposed drugs inhibit both entry pathways of SARS-CoV-2. Nature Communications, 2021. 12,1517. DOI: 10.1038/s41467-021-21825-w. (Mar 9, 2021). Impact factor: 17.694; Ranking of journal: 4/129. Times cited: 58 (Google Scholar)

      Significance: This is one of the first studies that we were developed a branched peptide 8P9R to more effectively inhibit the both entry pathways of SARS-CoV-2 infection (endocytosis and TMPRSS2 pathways).

    9.  Zhao HanJun#, To KK#, Sze KH#, Yung TT, Bian M, Lam H, Yeung ML, Li C, Chu H, Yuen KY. A broad-spectrum virus- and host-targeting peptide against respiratory viruses including influenza virus and SARS-CoV-2. Nature Communications, 2020 Aug 25;11(1):4252. doi: 10.1038/s41467-020-17986-9. Impact factor: 14.919; Ranking of journal in “Multidisciplinary”: 4/129;

      Significance: This is one of the first peptide that a basic mouse-defensin peptide targeting both virus and host can broadly inhibit influenza virus, SARS-CoV-2 and rhinovirus.

    10. Hanjun Zhao#, Kelvin K. W. To#, Hin Chu, Qiulu Ding, Xiaoyu Zhao, Cun Li, Huiping Shuai, Shuofeng Yuan, Jie Zhou, Kin-Hang Kok, Shibo Jiang, Kwok-Yung Yuen. Dual-functional peptide with defective interfering genes effectively protects mice against avian and seasonal influenza. Nature Communications, 2018, 9:2358. DOI: 10.1038/s41467-018-04792-7; (Jun 15, 2018). Impact factor: 17.694; Rank in Multidisciplinary Science: 6/73.

      Significance: This is the first report to demonstrate that defective interfering genes (DIG) can be a potent antiviral in vivo against avian and seasonal influenza virus.

    11. Hanjun Zhao, Jie Zhou, Ke Zhang, Dabin Liu, Vincent Kwok-Man Poon, Chris Chung-Sing Chan, Ho-Chuen Leung, Ng Fai, Yong-Ping Lin, Anna Jin-Xia Zhang, Dong-Yan Jin, Kwok-Yung Yuen, Bo-Jian Zheng. A novel peptide with potent and broad-spectrum antiviral activities against multiple respiratory viruses. Scientific Reports. 2016, 6:22008. DOI: 10.1038/srep22008. (Feb 15, 2016; 2021IF:4.996); Rank in Multidisciplinary Science: 19/73; Impact factor: 4.996; Rank in Multidisciplinary Science: 19/73.

      Significance: This is the first report to demonstrate that a basic peptide could broadly inhibit pH-dependent virus infection by interfering with viral entry through the endocytic pathway.

     

    Patents:

    1. Hanjun Zhao, Kwok-Yung Yuen. Antiviral Peptides and Methods of Use Thereof. US63/293,995. (Application: 2021-12-27-4H30)

    2. Hanjun Zhao, Kwok-Yung Yuen. Viral Nucleic Acid, Molecules, and Compositions and Methods of Use Thereof. US63/283,101 (Application: 2021-11-24-CoV-DIG)

    3. Hanjun Zhao, Kwok-Yung Yuen. Anti-viral Peptides and Compositions and Methods of Use Thereof. US63/150,141 (Application:2021-2-17-P16)

    4. Hanjun Zhao, Kwok-Yung Yuen. Anti-viral Peptides and Compositions and Methods of Use Thereof. PCT/CN2022/076453 (Application:2022-2-17-P16)

    5. Hanjun Zhao, Kwok-Yung Yuen. Compositions of Anti-viral Peptides and/or Compounds and Methods and Use Thereof. PCT/CN2021/125649 (Application: 2021-10-22)

    6. Hanjun Zhao, Kwok-Yung Yuen. Compositions of Anti-viral Peptides and/or Compounds and Methods and Use Thereof. US63/104,312. (Application:2020-10-22-8P9R)

    7. Hanjun Zhao, Kelvin K. W. To, Kwok-Yung Yuen. Compositions of Antiviral Peptides and Methods of the Use Thereof. PCT/CN2021/078639 (Application: 2021-3-02)

    8. Hanjun Zhao, Kelvin K. W. To, Kwok-Yung Yuen. Compositions of Antiviral Peptides and Methods of the Use Thereof. US62/991,407(Application: 2020-3-18-P9R)

    9. Hanjun Zhao, Kelvin K. W. To, Kwok-Yung Yuen. Nucleic Acid molecules and Dual-Functional Peptides Having Antiviral Activity and Delivery Activity, Compositions and Methods Thereof. EP19792753.6 (Application: 2020-10-17-IAV DIG and TAT-P1)

    10. Hanjun Zhao, Kelvin K. W. To, Kwok-Yung Yuen. Nucleic Acid molecules and Dual-Functional Peptides Having Antiviral Activity and Delivery Activity, Compositions and Methods Thereof. PCT/CN2019/084612 (Application: 2019-04-26)

    11. Hanjun Zhao, Kelvin K. W. To, Kwok-Yung Yuen. Nucleic Acid molecules and Dual-Functional Peptides Having Antiviral Activity and Delivery Activity, Compositions and Methods Thereof. US62/668,872 (Application: 2018-4-26)


    Assignee for approved patents: Guangzhou Xiangxue Pharmaceutical Co., Ltd

    1. Bojian Zheng, Hanjun Zhao. Peptides having activity of inhibiting infections of respiratory viruses, use of the same and methods of preparing the same. CA2910533C (Approved: 2018-07-31-P9)

    2. Bojian Zheng, Hanjun Zhao. Peptides Having Activity of Inhibiting Infections of Respiratory Viruses and Use of the Same. EP2994481B1 (Approved:2018-01-10-P9)

    3. Bojian Zheng, Hanjun Zhao. Peptides having activity of inhibiting infections of respiratory viruses, use of the same and methods of preparing the same. KR101800951B1 (Approved:2017-11-23-P9)

    4. Bojian Zheng, Hanjun Zhao. Peptides with inhibitory activity of the respiratory viral infection, its use, and its manufacturing method. JP6142077B2 (Approved:2017-06-07-P9)

    5. Bojian Zheng, Hanjun Zhao. Method of preventively treating a subject at the risk of developing infections of a respiratory virus. US9822155B2 (Approved:2017-11-21-P9).

    6. Bojian Zheng, Hanjun Zhao. Peptides having activity of inhibiting infections of respiratory viruses, use of the same and methods of preparing the same. MX346160B (Approved: 2017-03-08-P9)

    7. Bojian Zheng, Hanjun Zhao. Peptides having activity of inhibiting infections of respiratory viruses, use of the same and methods of preparing the same.AU2014262324B2 (Approved: 2016-08-04-P9)

    8. Bojian Zheng, Hanjun Zhao. Peptides that inhibit viral respiratory infections, their use and methods of preparation. RU2639559C2 (Approved:2017-12-21-P9)

    9. Bojian Zheng, Hanjun Zhao. Peptides Having Activity of Inhibiting Infections of Respiratory Viruses and Use of the Same. US9464123B2 (Approved:2016-10-11-P9)

    10. Bojian Zheng, Hanjun Zhao. Active peptides and methods of preparation and application of inhibiting viral infection of respiratory. CN103554244B (Approved:2016-09-07-P9)


  • 荣誉与奖励

    2024    Bronze Prize for Broad-spectrum antiviral peptides from the 49th International Exhibition of Inventions of Geneva, 2024

    2024    Bronze Prize for Dual-functional nanoparticle DIG against influenza virus and coronavirus from the 49th International Exhibition of Inventions of Geneva, 2024

    2023    Best Papers Award First Place, Emerging Microbes and Infections.

    2022    Faculty Outstanding Research Output Award, The University of Hong Kong. 2022

    2018    The Travel Award of the representatives of Hong Kong Young Scientists for the oral speaker in World Life Science Conference (Beijing 2018)


    欢迎对我们的研究方向感兴趣的学生或科研工作者加入我们团队。可将您的CV 发送到邮箱hanjunzhao@fudan.edu.cn。

    We are looking for highly motivated individuals to join us as MPhil/PhD students, or Research Assistants or Post-doctoral Fellows, Interested candidates please send a cover letter detailing your research interests and CV to Prof. HJ ZHAO (hanjunzhao@fudan.edu.cn).